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Distinct Binding Interactions of α(5)β(1)-Integrin and Proteoglycans with Fibronectin

Dynamic single-molecule force spectroscopy was performed to monitor the unbinding of fibronectin with the proteoglycans syndecan-4 (SDC4) and decorin and to compare this with the unbinding characteristics of α(5)β(1)-integrin. A single energy barrier was sufficient to describe the unbinding of both...

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Bibliographische Detailangaben
Veröffentlicht in:Biophys J
Hauptverfasser: Kennelly, Thomas M., Li, Yiran, Cao, Yi, Qwarnstrom, Eva E., Geoghegan, Mark
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Biophysical Society 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6712418/
https://ncbi.nlm.nih.gov/pubmed/31337547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2019.07.002
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