Extracellular Matrix From Hypertrophic Myocardium Provokes Impaired Twitch Dynamics in Healthy Cardiomyocytes

Hypertrophic cardiomyopathy (HCM) is often caused by single sarcomeric gene mutations that affect muscle contraction. Pharmacological correction of mutation effects prevents but does not reverse disease in mouse models. Suspecting that diseased extracellular matrix is to blame, we obtained myocardiu...

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Publicat a:JACC Basic Transl Sci
Autors principals: Sewanan, Lorenzo R., Schwan, Jonas, Kluger, Jonathan, Park, Jinkyu, Jacoby, Daniel L., Qyang, Yibing, Campbell, Stuart G.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2019
Matèries:
PRECLINICAL RESEARCH
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6712054/
https://ncbi.nlm.nih.gov/pubmed/31468004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2019.03.004
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