Extracellular Matrix From Hypertrophic Myocardium Provokes Impaired Twitch Dynamics in Healthy Cardiomyocytes

Hypertrophic cardiomyopathy (HCM) is often caused by single sarcomeric gene mutations that affect muscle contraction. Pharmacological correction of mutation effects prevents but does not reverse disease in mouse models. Suspecting that diseased extracellular matrix is to blame, we obtained myocardiu...

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Detaylı Bibliyografya
Yayımlandı:JACC Basic Transl Sci
Asıl Yazarlar: Sewanan, Lorenzo R., Schwan, Jonas, Kluger, Jonathan, Park, Jinkyu, Jacoby, Daniel L., Qyang, Yibing, Campbell, Stuart G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2019
Konular:
PRECLINICAL RESEARCH
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6712054/
https://ncbi.nlm.nih.gov/pubmed/31468004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2019.03.004
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