Extracellular Matrix From Hypertrophic Myocardium Provokes Impaired Twitch Dynamics in Healthy Cardiomyocytes

Hypertrophic cardiomyopathy (HCM) is often caused by single sarcomeric gene mutations that affect muscle contraction. Pharmacological correction of mutation effects prevents but does not reverse disease in mouse models. Suspecting that diseased extracellular matrix is to blame, we obtained myocardiu...

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Detalhes bibliográficos
Publicado no:JACC Basic Transl Sci
Main Authors: Sewanan, Lorenzo R., Schwan, Jonas, Kluger, Jonathan, Park, Jinkyu, Jacoby, Daniel L., Qyang, Yibing, Campbell, Stuart G.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
PRECLINICAL RESEARCH
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6712054/
https://ncbi.nlm.nih.gov/pubmed/31468004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2019.03.004
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