Loss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation

Hypertrophic cardiomyopathy (HCM) is an inherited disorder caused primarily by mutations to thick and thinfilament proteins. Although thin filament mutations are less prevalent than their oft-studied thick filament counterparts, they are frequently associated with severe patient phenotypes and can o...

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Gepubliceerd in:J Gen Physiol
Hoofdauteurs: Sewanan, Lorenzo R., Park, Jinkyu, Rynkiewicz, Michael J., Racca, Alice W., Papoutsidakis, Nikolaos, Schwan, Jonas, Jacoby, Daniel L., Moore, Jeffrey R., Lehman, William, Qyang, Yibing, Campbell, Stuart G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Rockefeller University Press 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8321830/
https://ncbi.nlm.nih.gov/pubmed/34319370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.202012640
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