Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a

CRISPR-Cas systems provide bacteria and archaea with programmable immunity against mobile genetic elements. Evolutionary pressure by CRISPR-Cas has driven bacteriophage to evolve small protein inhibitors, anti-CRISPRs (Acrs), that block Cas enzyme function by wide-ranging mechanisms. We show here th...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:eLife
Autori principali: Knott, Gavin J, Cress, Brady F, Liu, Jun-Jie, Thornton, Brittney W, Lew, Rachel J, Al-Shayeb, Basem, Rosenberg, Daniel J, Hammel, Michal, Adler, Benjamin A, Lobba, Marco J, Xu, Michael, Arkin, Adam P, Fellmann, Christof, Doudna, Jennifer A
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2019
Soggetti:
Biochemistry and Chemical Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6711708/
https://ncbi.nlm.nih.gov/pubmed/31397669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.49110
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi