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Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a
CRISPR-Cas systems provide bacteria and archaea with programmable immunity against mobile genetic elements. Evolutionary pressure by CRISPR-Cas has driven bacteriophage to evolve small protein inhibitors, anti-CRISPRs (Acrs), that block Cas enzyme function by wide-ranging mechanisms. We show here th...
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| 出版年: | eLife |
|---|---|
| 主要な著者: | , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
eLife Sciences Publications, Ltd
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6711708/ https://ncbi.nlm.nih.gov/pubmed/31397669 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.49110 |
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