Tobacco smoking induces changes in true DNA methylation, hydroxymethylation and gene expression in bronchoalveolar lavage cells

BACKGROUND: While smoking is known to associate with development of multiple diseases, the underlying mechanisms are still poorly understood. Tobacco smoking can modify the chemical integrity of DNA leading to changes in transcriptional activity, partly through an altered epigenetic state. We aimed...

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Veröffentlicht in:EBioMedicine
Hauptverfasser: Ringh, Mikael V., Hagemann-Jensen, Michael, Needhamsen, Maria, Kular, Lara, Breeze, Charles E., Sjöholm, Louise K., Slavec, Lara, Kullberg, Susanna, Wahlström, Jan, Grunewald, Johan, Brynedal, Boel, Liu, Yun, Almgren, Malin, Jagodic, Maja, Öckinger, Johan, Ekström, Tomas J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2019
Schlagworte:
Research paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6710853/
https://ncbi.nlm.nih.gov/pubmed/31303497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.07.006
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