Tobacco smoking induces changes in true DNA methylation, hydroxymethylation and gene expression in bronchoalveolar lavage cells

BACKGROUND: While smoking is known to associate with development of multiple diseases, the underlying mechanisms are still poorly understood. Tobacco smoking can modify the chemical integrity of DNA leading to changes in transcriptional activity, partly through an altered epigenetic state. We aimed...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Ringh, Mikael V., Hagemann-Jensen, Michael, Needhamsen, Maria, Kular, Lara, Breeze, Charles E., Sjöholm, Louise K., Slavec, Lara, Kullberg, Susanna, Wahlström, Jan, Grunewald, Johan, Brynedal, Boel, Liu, Yun, Almgren, Malin, Jagodic, Maja, Öckinger, Johan, Ekström, Tomas J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6710853/
https://ncbi.nlm.nih.gov/pubmed/31303497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.07.006
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