Constitutive Active Mutant TIE2 Induces Enlarged Vascular Lumen Formation with Loss of Apico-basal Polarity and Pericyte Recruitment

Abnormalities in controlling key aspects of angiogenesis including vascular cell migration, lumen formation and vessel maturation are hallmarks of vascular anomalies including venous malformation (VM). Gain-of-function mutations in the tyrosine kinase receptor TIE2 can cause VM and induce a ligand-i...

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Vydáno v:Sci Rep
Hlavní autoři: Cai, Yuqi, Schrenk, Sandra, Goines, Jillian, Davis, George E., Boscolo, Elisa
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6710257/
https://ncbi.nlm.nih.gov/pubmed/31451744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48854-2
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