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Rab35 GTPase couples cell division with initiation of epithelial apico-basal polarity and lumen opening

Establishment and maintenance of apico-basal polarity in epithelial organs must be tightly coupled with cell division, but the underlying molecular mechanisms are largely unknown. Using 3D cultures of renal MDCK cells (cysts), we found that the Rab35 GTPase plays a crucial role in polarity initiatio...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Klinkert, Kerstin, Rocancourt, Murielle, Houdusse, Anne, Echard, Arnaud
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822036/
https://ncbi.nlm.nih.gov/pubmed/27040773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11166
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