Securing the Payload, Finding the Cell, Avoiding the Endosome: Peptide-Targeted, Fusogenic Porous Silicon Nanoparticles for Delivery of siRNA

Despite the promise of RNAi therapeutics, the delivery of oligonucleotides selectively to diseased tissues in the body, and specifically to the cellular location in the tissues needed to provide optimal therapeutic outcome, remains a significant challenge. Here, key material properties and biologica...

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Bibliografische gegevens
Gepubliceerd in:Adv Mater
Hoofdauteurs: Kim, Byungji, Sun, Si, Varner, Judith A., Howell, Stephen B., Ruoslahti, Erkki, Sailor, Michael J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6710136/
https://ncbi.nlm.nih.gov/pubmed/31267590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adma.201902952
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