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Securing the Payload, Finding the Cell, Avoiding the Endosome: Peptide-Targeted, Fusogenic Porous Silicon Nanoparticles for Delivery of siRNA

Despite the promise of RNAi therapeutics, the delivery of oligonucleotides selectively to diseased tissues in the body, and specifically to the cellular location in the tissues needed to provide optimal therapeutic outcome, remains a significant challenge. Here, key material properties and biologica...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Adv Mater
Main Authors: Kim, Byungji, Sun, Si, Varner, Judith A., Howell, Stephen B., Ruoslahti, Erkki, Sailor, Michael J.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6710136/
https://ncbi.nlm.nih.gov/pubmed/31267590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adma.201902952
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