Self-Sealing Porous Silicon-Calcium Silicate Core-Shell Nanoparticles for Targeted siRNA Delivery to the Injured Brain

A single-step procedure to simultaneously load and protect high concentrations of siRNA in porous silicon nanoparticles (pSiNPs) is presented. Treatment of pSiNPs with an aqueous solution containing siRNA and calcium chloride generates core-shell nanostructures consisting of an siRNA-loaded pSiNP co...

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Detalhes bibliográficos
Publicado no:Adv Mater
Main Authors: Kang, Jinyoung, Joo, Jinmyoung, Kwon, E. Ester, Skalak, Matthew, Hussain, Sazid, She, Zhi-gang, Ruoslahti, Erkki, Bhatia, Sangeeta N., Sailor, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6274592/
https://ncbi.nlm.nih.gov/pubmed/27383373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adma.201600634
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