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Porous silicon–graphene oxide core–shell nanoparticles for targeted delivery of siRNA to the injured brain

We report the synthesis, characterization, and assessment of a nanoparticle-based RNAi delivery platform that protects siRNA payloads against nuclease-induced degradation and efficiently delivers them to target cells. The nanocarrier is based on biodegradable mesoporous silicon nanoparticles (pSiNPs...

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Détails bibliographiques
Publié dans:Nanoscale Horiz
Auteurs principaux: Joo, Jinmyoung, Kwon, Ester J., Kang, Jinyoung, Skalak, Matthew, Anglin, Emily J., Mann, Aman P., Ruoslahti, Erkki, Bhatia, Sangeeta N., Sailor, Michael J.
Format: Artigo
Langue:Inglês
Publié: 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5935492/
https://ncbi.nlm.nih.gov/pubmed/29732165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C6NH00082G
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