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In-solution enrichment identifies peptide inhibitors of protein–protein interactions
The use of competitive inhibitors to disrupt protein–protein interactions (PPIs) holds great promise for the treatment of disease. However, the discovery of high-affinity inhibitors can be a challenge. Here we report a platform for improving the affinity of peptide-based PPI inhibitors using non-can...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Nat Chem Biol |
|---|---|
| Prif Awduron: | , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2019
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6710073/ https://ncbi.nlm.nih.gov/pubmed/30886434 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-019-0245-2 |
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