Dysregulation of histone H3 lysine 27 trimethylation in transforming growth factor-β1–induced gene expression in mesangial cells and diabetic kidney

Transforming growth factor-β1 (TGF-β)-induced fibrotic and inflammatory genes in renal mesangial cells (MCs) play important roles in glomerular dysfunction associated with diabetic nephropathy (DN). TGF-β regulates gene expression in MCs by altering key chromatin histone modifications at target gene...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Jia, Ye, Reddy, Marpadga A., Das, Sadhan, Oh, Hyung Jung, Abdollahi, Maryam, Yuan, Hang, Zhang, Erli, Lanting, Linda, Wang, Mei, Natarajan, Rama
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2019
Soggetti:
Molecular Bases of Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709639/
https://ncbi.nlm.nih.gov/pubmed/31266808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007575
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