A cysteinyl-tRNA synthetase variant confers resistance against selenite toxicity and decreases selenocysteine misincorporation

Selenocysteine (Sec) is the 21st genetically encoded amino acid in organisms across all domains of life. Although structurally similar to cysteine (Cys), the Sec selenol group has unique properties that are attractive for protein engineering and biotechnology applications. Production of designer pro...

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Vydáno v:J Biol Chem
Hlavní autoři: Hoffman, Kyle S., Vargas-Rodriguez, Oscar, Bak, Daniel W., Mukai, Takahito, Woodward, Laura K., Weerapana, Eranthie, Söll, Dieter, Reynolds, Noah M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Protein Synthesis and Degradation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709638/
https://ncbi.nlm.nih.gov/pubmed/31296657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008219
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