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A cysteinyl-tRNA synthetase variant confers resistance against selenite toxicity and decreases selenocysteine misincorporation

Selenocysteine (Sec) is the 21st genetically encoded amino acid in organisms across all domains of life. Although structurally similar to cysteine (Cys), the Sec selenol group has unique properties that are attractive for protein engineering and biotechnology applications. Production of designer pro...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Hoffman, Kyle S., Vargas-Rodriguez, Oscar, Bak, Daniel W., Mukai, Takahito, Woodward, Laura K., Weerapana, Eranthie, Söll, Dieter, Reynolds, Noah M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709638/
https://ncbi.nlm.nih.gov/pubmed/31296657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008219
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