A Minimal Physiologically‐Based Pharmacokinetic Model for Tacrolimus in Living‐Donor Liver Transplantation: Perspectives Related to Liver Regeneration and the cytochrome P450 3A5 (CYP3A5) Genotype

In adult patients after living‐donor liver transplantation, postoperative days and the cytochrome P450 3A5 (CYP3A5) genotype are known to affect tacrolimus pharmacokinetics. In this study, we constructed a physiologically‐based pharmacokinetic model adapted to the clinical data and evaluated the con...

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Foilsithe in:CPT Pharmacometrics Syst Pharmacol
Main Authors: Itohara, Kotaro, Yano, Ikuko, Tsuzuki, Tetsunori, Uesugi, Miwa, Nakagawa, Shunsaku, Yonezawa, Atsushi, Okajima, Hideaki, Kaido, Toshimi, Uemoto, Shinji, Matsubara, Kazuo
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley and Sons Inc. 2019
Ábhair:
Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709420/
https://ncbi.nlm.nih.gov/pubmed/31087501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12420
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