A Minimal Physiologically‐Based Pharmacokinetic Model for Tacrolimus in Living‐Donor Liver Transplantation: Perspectives Related to Liver Regeneration and the cytochrome P450 3A5 (CYP3A5) Genotype

In adult patients after living‐donor liver transplantation, postoperative days and the cytochrome P450 3A5 (CYP3A5) genotype are known to affect tacrolimus pharmacokinetics. In this study, we constructed a physiologically‐based pharmacokinetic model adapted to the clinical data and evaluated the con...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:CPT Pharmacometrics Syst Pharmacol
मुख्य लेखकों: Itohara, Kotaro, Yano, Ikuko, Tsuzuki, Tetsunori, Uesugi, Miwa, Nakagawa, Shunsaku, Yonezawa, Atsushi, Okajima, Hideaki, Kaido, Toshimi, Uemoto, Shinji, Matsubara, Kazuo
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: John Wiley and Sons Inc. 2019
विषय:
Research
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709420/
https://ncbi.nlm.nih.gov/pubmed/31087501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12420
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