A Minimal Physiologically‐Based Pharmacokinetic Model for Tacrolimus in Living‐Donor Liver Transplantation: Perspectives Related to Liver Regeneration and the cytochrome P450 3A5 (CYP3A5) Genotype

In adult patients after living‐donor liver transplantation, postoperative days and the cytochrome P450 3A5 (CYP3A5) genotype are known to affect tacrolimus pharmacokinetics. In this study, we constructed a physiologically‐based pharmacokinetic model adapted to the clinical data and evaluated the con...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:CPT Pharmacometrics Syst Pharmacol
Egile Nagusiak: Itohara, Kotaro, Yano, Ikuko, Tsuzuki, Tetsunori, Uesugi, Miwa, Nakagawa, Shunsaku, Yonezawa, Atsushi, Okajima, Hideaki, Kaido, Toshimi, Uemoto, Shinji, Matsubara, Kazuo
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2019
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709420/
https://ncbi.nlm.nih.gov/pubmed/31087501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12420
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