Synthesis, characterization, and mechanistic studies of a gold nanoparticle–amphotericin B covalent conjugate with enhanced antileishmanial efficacy and reduced cytotoxicity

BACKGROUND: Amphotericin B (AmB) as a liposomal formulation of AmBisome is the first line of treatment for the disease, visceral leishmaniasis, caused by the parasite Leishmania donovani. However, nephrotoxicity is very common due to poor water solubility and aggregation of AmB. This study aimed to...

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Detalhes bibliográficos
Publicado no:Int J Nanomedicine
Main Authors: Kumar, Prakash, Shivam, Pushkar, Mandal, Saptarshi, Prasanna, Pragya, Kumar, Saurabh, Prasad, Surendra Rajit, Kumar, Ashish, Das, Prolay, Ali, Vahab, Singh, Shubhankar Kumar, Mandal, Debabrata
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2019
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709383/
https://ncbi.nlm.nih.gov/pubmed/31686803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S196421
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