Ultraviolet light induces increased T cell activation in lupus-prone mice via type I IFN-dependent inhibition of T regulatory cells

Ultraviolet (UV) light is a known trigger of skin and possibly systemic inflammation in systemic lupus erythematosus (SLE) patients. Although type I interferons (IFN) are upregulated in SLE skin after UV exposure, the mechanisms to explain increased UVB-induced inflammation remain unclear. This pape...

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Pubblicato in:J Autoimmun
Autori principali: Wolf, Sonya J., Estadt, Shannon N., Theros, Jonathan, Moore, Tyson, Ellis, Jason, Liu, Jianhua, Reed, Tamra J., Jacob, Chaim O., Gudjonsson, Johann E., Kahlenberg, J. Michelle
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6708464/
https://ncbi.nlm.nih.gov/pubmed/31248690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2019.06.002
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