Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing

BACKGROUND: DNA methylation changes with age. Chronological age predictors built from DNA methylation are termed ‘epigenetic clocks’. The deviation of predicted age from the actual age (‘age acceleration residual’, AAR) has been reported to be associated with death. However, it is currently unclear...

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Publicado en:Genome Med
Main Authors: Zhang, Qian, Vallerga, Costanza L., Walker, Rosie M., Lin, Tian, Henders, Anjali K., Montgomery, Grant W., He, Ji, Fan, Dongsheng, Fowdar, Javed, Kennedy, Martin, Pitcher, Toni, Pearson, John, Halliday, Glenda, Kwok, John B., Hickie, Ian, Lewis, Simon, Anderson, Tim, Silburn, Peter A., Mellick, George D., Harris, Sarah E., Redmond, Paul, Murray, Alison D., Porteous, David J., Haley, Christopher S., Evans, Kathryn L., McIntosh, Andrew M., Yang, Jian, Gratten, Jacob, Marioni, Riccardo E., Wray, Naomi R., Deary, Ian J., McRae, Allan F., Visscher, Peter M.
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2019
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6708158/
https://ncbi.nlm.nih.gov/pubmed/31443728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-019-0667-1
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