Functional Reprogramming of Regulatory T cells in the absence of Foxp3

Regulatory T cells (T(reg) cells) deficient in the transcription factor Foxp3 lack suppressor function and manifest a T effector (T(eff)) cell-like phenotype. We demonstrate that Foxp3 deficiency dysregulates metabolic checkpoint kinase mTORC2 signaling and gives rise to augmented aerobic glycolysis...

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Pubblicato in:Nat Immunol
Autori principali: Charbonnier, Louis-Marie, Cui, Ye, Victor, Emmanuel, Harb, Hani, Lopez, David, Bleesing, Jack J, Garcia-Lloret, Maria I, Chen, Karin, Ozen, Ahmet, Carmeliet, Peter, Li, Ming O, Pellegrini, Matteo, Chatila, Talal A
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6707855/
https://ncbi.nlm.nih.gov/pubmed/31384057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-019-0442-x
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