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An asthma-associated IL4R variant exacerbates airway inflammation by promoting conversion of regulatory T cells to T(H)17-like cells
Mechanisms by which regulatory T (T(reg)) cells fail to control inflammation in asthma remain poorly understood. We show that a severe asthma-associated polymorphism in the interleukin-4 receptor alpha chain (IL4RA R576) promotes conversion of induced T(reg) (iT(reg)) cells towards a T helper 17 (T(...
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| Publicado no: | Nat Med |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5014738/ https://ncbi.nlm.nih.gov/pubmed/27479084 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4147 |
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