Hepatic SIRT3 Upregulation in Response to Chronic Alcohol Consumption Contributes to Alcoholic Liver Disease in Mice

BACKGROUND: Alcoholic liver disease (ALD) is a type of chronic liver disease caused by chronic ethanol overconsumption. The pathogenesis of ALD is complex and there is no effective clinical treatment thus far. SIRT3 is an NAD(+)-dependent deacetylase primarily located inside mitochondria, and report...

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Publicado en:Front Physiol
Autores principales: Ma, Yue, Chai, Hui, Ding, Qinchao, Qian, Qianyu, Yan, Zhaoyuan, Ding, Bin, Dou, Xiaobing, Li, Songtao
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2019
Materias:
Physiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6707764/
https://ncbi.nlm.nih.gov/pubmed/31474877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2019.01042
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