A Mouse Thyrotropin Receptor A-Subunit Transgene Expressed in Thyroiditis-Prone Mice May Provide Insight into Why Graves' Disease Only Occurs in Humans

Background: Graves' disease, caused by autoantibodies that activate the thyrotropin (TSH) receptor (TSHR), has only been reported in humans. Thyroiditis-prone NOD.H2(h4) mice develop autoantibodies to thyroglobulin (Tg) and thyroid peroxidase (TPO) but not to the TSHR. Evidence supports the imp...

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Veröffentlicht in:Thyroid
Hauptverfasser: McLachlan, Sandra M., Aliesky, Holly A., Rapoport, Basil
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc., publishers 2019
Schlagworte:
Immunology, Autoimmunity, and Graves Ophthalmopathy
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6707033/
https://ncbi.nlm.nih.gov/pubmed/31184281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/thy.2019.0260
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