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Anomalous enhancement of resurgent Na(+) currents at high temperatures by SCN9A mutations underlies the episodic heat-enhanced pain in inherited erythromelalgia

Inherited erythromelalgia (IEM), caused by mutations in Na(v)1.7 channel is characterized by episodic neuropathic pain triggered especially by warm temperature. However, the mechanism underlying the temperature–dependent episodic attacks of IEM remains elusive. We investigated the electrophysiologic...

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書目詳細資料
發表在:Sci Rep
Main Authors: Huang, Chiung-Wei, Lai, Hsing-Jung, Huang, Po-Yuan, Lee, Ming-Jen, Kuo, Chung-Chin
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6706385/
https://ncbi.nlm.nih.gov/pubmed/31439884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48672-6
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