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Anomalous enhancement of resurgent Na(+) currents at high temperatures by SCN9A mutations underlies the episodic heat-enhanced pain in inherited erythromelalgia

Inherited erythromelalgia (IEM), caused by mutations in Na(v)1.7 channel is characterized by episodic neuropathic pain triggered especially by warm temperature. However, the mechanism underlying the temperature–dependent episodic attacks of IEM remains elusive. We investigated the electrophysiologic...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Huang, Chiung-Wei, Lai, Hsing-Jung, Huang, Po-Yuan, Lee, Ming-Jen, Kuo, Chung-Chin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6706385/
https://ncbi.nlm.nih.gov/pubmed/31439884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48672-6
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