SCN10A Mutation in a Patient with Erythromelalgia Enhances C-Fiber Activity Dependent Slowing

Gain-of-function mutations in the tetrodotoxin (TTX) sensitive voltage-gated sodium channel (Nav) Nav1.7 have been identified as a key mechanism underlying chronic pain in inherited erythromelalgia. Mutations in TTX resistant channels, such as Nav1.8 or Nav1.9, were recently connected with inherited...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kist, Andreas M., Sagafos, Dagrun, Rush, Anthony M., Neacsu, Cristian, Eberhardt, Esther, Schmidt, Roland, Lunden, Lars Kristian, Ørstavik, Kristin, Kaluza, Luisa, Meents, Jannis, Zhang, Zhiping, Carr, Thomas Hedley, Salter, Hugh, Malinowsky, David, Wollberg, Patrik, Krupp, Johannes, Kleggetveit, Inge Petter, Schmelz, Martin, Jørum, Ellen, Lampert, Angelika, Namer, Barbara
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012686/
https://ncbi.nlm.nih.gov/pubmed/27598514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0161789
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