SCN10A Mutation in a Patient with Erythromelalgia Enhances C-Fiber Activity Dependent Slowing

Gain-of-function mutations in the tetrodotoxin (TTX) sensitive voltage-gated sodium channel (Nav) Nav1.7 have been identified as a key mechanism underlying chronic pain in inherited erythromelalgia. Mutations in TTX resistant channels, such as Nav1.8 or Nav1.9, were recently connected with inherited...

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Bibliografische gegevens
Gepubliceerd in:PLoS One
Hoofdauteurs: Kist, Andreas M., Sagafos, Dagrun, Rush, Anthony M., Neacsu, Cristian, Eberhardt, Esther, Schmidt, Roland, Lunden, Lars Kristian, Ørstavik, Kristin, Kaluza, Luisa, Meents, Jannis, Zhang, Zhiping, Carr, Thomas Hedley, Salter, Hugh, Malinowsky, David, Wollberg, Patrik, Krupp, Johannes, Kleggetveit, Inge Petter, Schmelz, Martin, Jørum, Ellen, Lampert, Angelika, Namer, Barbara
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2016
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012686/
https://ncbi.nlm.nih.gov/pubmed/27598514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0161789
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