The role of Na(v)1.7 in human nociceptors: insights from human induced pluripotent stem cell–derived sensory neurons of erythromelalgia patients

The chronic pain syndrome inherited erythromelalgia (IEM) is attributed to mutations in the voltage-gated sodium channel (Na(V)) 1.7. Still, recent studies targeting Na(V)1.7 in clinical trials have provided conflicting results. Here, we differentiated induced pluripotent stem cells from IEM patient...

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Detalhes bibliográficos
Publicado no:Pain
Main Authors: Meents, Jannis E., Bressan, Elisangela, Sontag, Stephanie, Foerster, Alec, Hautvast, Petra, Rösseler, Corinna, Hampl, Martin, Schüler, Herdit, Goetzke, Roman, Le, Thi Kim Chi, Kleggetveit, Inge Petter, Le Cann, Kim, Kerth, Clara, Rush, Anthony M., Rogers, Marc, Kohl, Zacharias, Schmelz, Martin, Wagner, Wolfgang, Jørum, Ellen, Namer, Barbara, Winner, Beate, Zenke, Martin, Lampert, Angelika
Formato: Artigo
Idioma:Inglês
Publicado em: Wolters Kluwer 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554007/
https://ncbi.nlm.nih.gov/pubmed/30720580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/j.pain.0000000000001511
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