The role of Na(v)1.7 in human nociceptors: insights from human induced pluripotent stem cell–derived sensory neurons of erythromelalgia patients

The chronic pain syndrome inherited erythromelalgia (IEM) is attributed to mutations in the voltage-gated sodium channel (Na(V)) 1.7. Still, recent studies targeting Na(V)1.7 in clinical trials have provided conflicting results. Here, we differentiated induced pluripotent stem cells from IEM patient...

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Dettagli Bibliografici
Pubblicato in:Pain
Autori principali: Meents, Jannis E., Bressan, Elisangela, Sontag, Stephanie, Foerster, Alec, Hautvast, Petra, Rösseler, Corinna, Hampl, Martin, Schüler, Herdit, Goetzke, Roman, Le, Thi Kim Chi, Kleggetveit, Inge Petter, Le Cann, Kim, Kerth, Clara, Rush, Anthony M., Rogers, Marc, Kohl, Zacharias, Schmelz, Martin, Wagner, Wolfgang, Jørum, Ellen, Namer, Barbara, Winner, Beate, Zenke, Martin, Lampert, Angelika
Natura: Artigo
Lingua:Inglês
Pubblicazione: Wolters Kluwer 2019
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554007/
https://ncbi.nlm.nih.gov/pubmed/30720580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/j.pain.0000000000001511
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