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Development and validation of an allele-specific PCR assay for genotyping a promoter and exonic single nucleotide polymorphisms of MGMT gene
DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) specifically remove the methyl/alkyl group from the O(6)-position of guanine and restore the guanine to its normal form without causing DNA strand breaks. Relationship between MGMT activity and resistance to alkylating therapeutic ag...
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| Pubblicato in: | J Biol Methods |
|---|---|
| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Journal of Biological Methods
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6706101/ https://ncbi.nlm.nih.gov/pubmed/31453242 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14440/jbm.2018.224 |
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