Development and validation of an allele-specific PCR assay for genotyping a promoter and exonic single nucleotide polymorphisms of MGMT gene

DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) specifically remove the methyl/alkyl group from the O(6)-position of guanine and restore the guanine to its normal form without causing DNA strand breaks. Relationship between MGMT activity and resistance to alkylating therapeutic ag...

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Bibliographic Details
Published in:J Biol Methods
Main Authors: Tyagi, Anuj Kumar, Khoshbeen, Mary Boudal, Curtis, Patricia Huezo-Diaz, Uppugunduri, Chakradhara Rao S., Ansari, Marc
Format: Artigo
Language:Inglês
Published: Journal of Biological Methods 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6706101/
https://ncbi.nlm.nih.gov/pubmed/31453242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14440/jbm.2018.224
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