α(2)δ2 Controls the Function and Trans-Synaptic Coupling of Ca(v)1.3 Channels in Mouse Inner Hair Cells and Is Essential for Normal Hearing

The auxiliary subunit α(2)δ2 modulates the abundance and function of voltage-gated calcium channels. Here we show that α(2)δ2 mRNA is expressed in neonatal and mature hair cells. A functional α(2)δ2-null mouse, the ducky mouse (du), showed elevated auditory brainstem response click and frequency-dep...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Fell, Barbara, Eckrich, Stephanie, Blum, Kerstin, Eckrich, Tobias, Hecker, Dietmar, Obermair, Gerald J., Münkner, Stefan, Flockerzi, Veit, Schick, Bernhard, Engel, Jutta
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2016
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6705655/
https://ncbi.nlm.nih.gov/pubmed/27798183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3468-14.2016
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