Cochlea-Specific Deletion of Ca(v)1.3 Calcium Channels Arrests Inner Hair Cell Differentiation and Unravels Pitfalls of Conditional Mouse Models

Inner hair cell (IHC) Ca(v)1.3 Ca(2+) channels are multifunctional channels mediating Ca(2+) influx for exocytosis at ribbon synapses, the generation of Ca(2+) action potentials in pre-hearing IHCs and gene expression. IHCs of deaf systemic Ca(v)1.3-deficient (Ca(v)1.3(-/-)) mice stay immature becau...

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Udgivet i:Front Cell Neurosci
Main Authors: Eckrich, Stephanie, Hecker, Dietmar, Sorg, Katharina, Blum, Kerstin, Fischer, Kerstin, Münkner, Stefan, Wenzel, Gentiana, Schick, Bernhard, Engel, Jutta
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6538774/
https://ncbi.nlm.nih.gov/pubmed/31178698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2019.00225
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