Deletion of Abca7 Increases Cerebral Amyloid-β Accumulation in the J20 Mouse Model of Alzheimer's Disease

ATP-binding cassette transporter A7 (ABCA7) is expressed in the brain and has been detected in macrophages, microglia, and neurons. ABCA7 promotes efflux of lipids from cells to apolipoproteins and can also regulate phagocytosis and modulate processing of amyloid precursor protein (APP) to generate...

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Udgivet i:J Neurosci
Main Authors: Kim, Woojin S., Li, Hongyun, Ruberu, Kalani, Chan, Sharon, Elliott, David A., Low, Jac Kee, Cheng, David, Karl, Tim, Garner, Brett
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2013
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6704948/
https://ncbi.nlm.nih.gov/pubmed/23467355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4165-12.2013
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