Deficiency and haploinsufficiency of histone macroH2A1.1 in mice recapitulate hematopoietic defects of human myelodysplastic syndrome

BACKGROUND: Epigenetic regulation is important in hematopoiesis, but the involvement of histone variants is poorly understood. Myelodysplastic syndromes (MDS) are heterogeneous clonal hematopoietic stem cell (HSC) disorders characterized by ineffective hematopoiesis. MacroH2A1.1 is a histone H2A var...

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Publicat a:Clin Epigenetics
Autors principals: Bereshchenko, Oxana, Lo Re, Oriana, Nikulenkov, Fedor, Flamini, Sara, Kotaskova, Jana, Mazza, Tommaso, Le Pannérer, Marguerite-Marie, Buschbeck, Marcus, Giallongo, Cesarina, Palumbo, Giuseppe, Li Volti, Giovanni, Pazienza, Valerio, Cervinek, Libor, Riccardi, Carlo, Krejci, Lumir, Pospisilova, Sarka, Stewart, A. Francis, Vinciguerra, Manlio
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6704528/
https://ncbi.nlm.nih.gov/pubmed/31439048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-019-0724-z
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