Loss of histone macroH2A1 in hepatocellular carcinoma cells promotes paracrine-mediated chemoresistance and CD4(+)CD25(+)FoxP3(+) regulatory T cells activation

Rationale: Loss of histone macroH2A1 induces appearance of cancer stem cells (CSCs)-like cells in hepatocellular carcinoma (HCC). How CSCs interact with the tumor microenvironment and the adaptive immune system is unclear. Methods: We screened aggressive human HCC for macroH2A1 and CD44 CSC marker e...

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Опубликовано в: :Theranostics
Главные авторы: Lo Re, Oriana, Mazza, Tommaso, Giallongo, Sebastiano, Sanna, Paola, Rappa, Francesca, Vinh Luong, Tu, Li Volti, Giovanni, Drovakova, Adela, Roskams, Tania, Van Haele, Matthias, Tsochatzis, Emmanuel, Vinciguerra, Manlio
Формат: Artigo
Язык:Inglês
Опубликовано: Ivyspring International Publisher 2020
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6929991/
https://ncbi.nlm.nih.gov/pubmed/31903159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.35045
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