Ouabain-regulated phosphoproteome reveals molecular mechanisms for Na(+), K(+)–ATPase control of cell adhesion, proliferation, and survival

The ion pump Na(+), K(+)–ATPase (NKA) is a receptor for the cardiotonic steroid ouabain. Subsaturating concentration of ouabain triggers intracellular calcium oscillations, stimulates cell proliferation and adhesion, and protects from apoptosis. However, it is controversial whether ouabain-bound NKA...

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Detalles Bibliográficos
Publicado en:FASEB J
Autores principales: Panizza, Elena, Zhang, Liang, Fontana, Jacopo Maria, Hamada, Kozo, Svensson, Daniel, Akkuratov, Evgeny E., Scott, Lena, Mikoshiba, Katsuhiko, Brismar, Hjalmar, Lehtiö, Janne, Aperia, Anita
Formato: Artigo
Lenguaje:Inglês
Publicado: Federation of American Societies for Experimental Biology 2019
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6704450/
https://ncbi.nlm.nih.gov/pubmed/31199885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201900445R
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