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Exhaustion of CD4+ T-cells mediated by the Kynurenine Pathway in Melanoma
Kynurenine pathway (KP) activation by the enzymatic activity of indoleamine 2,3-dioxygenase1 (IDO1) and kynurenine (KYN) production represents an attractive target for reducing tumour progression and improving anti-tumour immunity in multiple cancers. However, immunomodulatory properties of other KP...
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| Publicat a: | Sci Rep |
|---|---|
| Autors principals: | , , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6704156/ https://ncbi.nlm.nih.gov/pubmed/31434983 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48635-x |
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