The Histone Methyltransferase Setdb2 Modulates Macrophage Phenotype and Uric Acid Production in Diabetic Wound Repair

Macrophage plasticity is critical for normal tissue repair to ensure transition from the inflammatory to the proliferative phase of healing. We examined macrophages isolated from wounds of patients afflicted with diabetes and of healthy controls and found differential expression of the methyltransfe...

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Veröffentlicht in:Immunity
Hauptverfasser: Kimball, Andrew S., Davis, Frank M., denDekker, Aaron, Joshi, Amrita D., Schaller, Matthew A., Bermick, Jennifer, Xing, Xianying, Burant, Charles F., Obi, Andrea T., Nysz, Dylan, Robinson, Scott, Allen, Ron, Lukacs, Nicholas W., Henke, Peter K., Gudjonsson, Johann E., Moore, Bethany B., Kunkel, Steve L., Gallagher, Katherine A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6703945/
https://ncbi.nlm.nih.gov/pubmed/31350176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2019.06.015
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