Calpains Are Downstream Effectors of bax-Dependent Excitotoxic Apoptosis

Excitotoxicity resulting from excessive Ca(2+) influx through glutamate receptors contributes to neuronal injury after stroke, trauma, and seizures. Increased cytosolic Ca(2+) levels activate a family of calcium-dependent proteases with papain-like activity, the calpains. Here we investigated the ro...

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Vydáno v:J Neurosci
Hlavní autoři: D'Orsi, Beatrice, Bonner, Helena, Tuffy, Liam P., Düssmann, Heiko, Woods, Ina, Courtney, Michael J., Ward, Manus W., Prehn, Jochen H. M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6703363/
https://ncbi.nlm.nih.gov/pubmed/22302823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2345-11.2012
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