Characterization of Puma-Dependent and Puma-Independent Neuronal Cell Death Pathways following Prolonged Proteasomal Inhibition

Proteasomal stress and the accumulation of polyubiquitinated proteins are key features of numerous neurodegenerative disorders. Previously we demonstrated that stabilization of p53 and activation of its target gene, puma (p53-upregulated mediator of apoptosis), mediated proteasome inhibitor-induced...

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Detalhes bibliográficos
Main Authors: Tuffy, Liam P., Concannon, Caoimhín G., D'Orsi, Beatrice, King, Matthew A., Woods, Ina, Huber, Heinrich J., Ward, Manus W., Prehn, Jochen H. M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976426/
https://ncbi.nlm.nih.gov/pubmed/20921277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00575-10
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