A Long-Acting PYY(3–36) Analog Mediates Robust Anorectic Efficacy with Minimal Emesis in Nonhuman Primates

The gut hormone PYY(3–36) reduces food intake in humans and exhibits at least additive efficacy in combination with GLP-1. However, the utility of PYY analogs as anti-obesity agents has been severely limited by emesis and rapid proteolysis, a profile similarly observed with native PYY(3–36) in obese...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Cell Metab
Main Authors: Rangwala, Shamina M., D’Aquino, Katharine, Zhang, Yue-Mei, Bader, Lindsay, Edwards, Wilson, Zheng, Songmao, Eckardt, Annette, Lacombe, Ann, Pick, Rebecca, Moreno, Veronica, Kang, Lijuan, Jian, Wenying, Arnoult, Eric, Case, Martin, Jenkinson, Celia, Chi, Ellen, Swanson, Ronald V., Kievit, Paul, Grove, Kevin, Macielag, Mark, Erion, Mark D., SinhaRoy, Ranabir, Leonard, James N.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2019
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6701930/
https://ncbi.nlm.nih.gov/pubmed/30773465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2019.01.017
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