A Long-Acting PYY(3–36) Analog Mediates Robust Anorectic Efficacy with Minimal Emesis in Nonhuman Primates

The gut hormone PYY(3–36) reduces food intake in humans and exhibits at least additive efficacy in combination with GLP-1. However, the utility of PYY analogs as anti-obesity agents has been severely limited by emesis and rapid proteolysis, a profile similarly observed with native PYY(3–36) in obese...

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Udgivet i:Cell Metab
Main Authors: Rangwala, Shamina M., D’Aquino, Katharine, Zhang, Yue-Mei, Bader, Lindsay, Edwards, Wilson, Zheng, Songmao, Eckardt, Annette, Lacombe, Ann, Pick, Rebecca, Moreno, Veronica, Kang, Lijuan, Jian, Wenying, Arnoult, Eric, Case, Martin, Jenkinson, Celia, Chi, Ellen, Swanson, Ronald V., Kievit, Paul, Grove, Kevin, Macielag, Mark, Erion, Mark D., SinhaRoy, Ranabir, Leonard, James N.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6701930/
https://ncbi.nlm.nih.gov/pubmed/30773465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2019.01.017
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