Systems Biology Analyses Reveal Hyperactivation of Transforming Growth Factor beta and JNK Signaling pathways in Esophageal Cancer

BACKGROUND & AIMS: Esophageal adenocarcinoma (EAC) is resistant to standard chemoradiation treatments and few targeted therapies are available. We used large-scale tissue profiling and pharmacogenetic analyses to identify deregulated signaling pathways in EAC tissues that might be targeted to sl...

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Publicado no:Gastroenterology
Main Authors: Blum, Andrew E., Venkitachalam, Srividya, Ravillah, Durgadevi, Chelluboyina, Aruna K., Kieber-Emmons, Ann Marie, Ravi, Lakshmeswari, Kresak, Adam, Chandar, Apoorva K., Markowitz, Sanford D., Canto, Marcia I., Wang, Jean S., Shaheen, Nicholas J., Guo, Yan, Shyr, Yu, Willis, Joseph E., Chak, Amitabh, Varadan, Vinay, Guda, Kishore
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6701681/
https://ncbi.nlm.nih.gov/pubmed/30768984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2019.01.263
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