Systems Biology Analyses Reveal Hyperactivation of Transforming Growth Factor beta and JNK Signaling pathways in Esophageal Cancer

BACKGROUND & AIMS: Esophageal adenocarcinoma (EAC) is resistant to standard chemoradiation treatments and few targeted therapies are available. We used large-scale tissue profiling and pharmacogenetic analyses to identify deregulated signaling pathways in EAC tissues that might be targeted to sl...

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Vydáno v:Gastroenterology
Hlavní autoři: Blum, Andrew E., Venkitachalam, Srividya, Ravillah, Durgadevi, Chelluboyina, Aruna K., Kieber-Emmons, Ann Marie, Ravi, Lakshmeswari, Kresak, Adam, Chandar, Apoorva K., Markowitz, Sanford D., Canto, Marcia I., Wang, Jean S., Shaheen, Nicholas J., Guo, Yan, Shyr, Yu, Willis, Joseph E., Chak, Amitabh, Varadan, Vinay, Guda, Kishore
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6701681/
https://ncbi.nlm.nih.gov/pubmed/30768984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2019.01.263
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