Mechanistic Insights of Phenobarbital-Mediated Activation of Human but Not Mouse Pregnane X Receptor

Phenobarbital (PB), a broadly used antiseizure drug, was the first to be characterized as an inducer of cytochrome P450 by activation of the constitutive androstane receptor (CAR). Although PB is recognized as a conserved CAR activator among species via a well-documented indirect activation mechanis...

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Udgivet i:Mol Pharmacol
Main Authors: Li, Linhao, Welch, Matthew A., Li, Zhihui, Mackowiak, Bryan, Heyward, Scott, Swaan, Peter W., Wang, Hongbing
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2019
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6701513/
https://ncbi.nlm.nih.gov/pubmed/31436536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.119.116616
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