SLC13A5 Is a Novel Transcriptional Target of the Pregnane X Receptor and Sensitizes Drug-Induced Steatosis in Human Liver

The solute carrier family 13 member 5 (SLC13A5) is a sodium-coupled transporter that mediates cellular uptake of citrate, which plays important roles in the synthesis of fatty acids and cholesterol. Recently, the pregnane X receptor (PXR, NR1I2), initially characterized as a xenobiotic sensor, has b...

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Veröffentlicht in:Mol Pharmacol
Hauptverfasser: Li, Linhao, Li, Haishan, Garzel, Brandy, Yang, Hui, Sueyoshi, Tatsuya, Li, Qing, Shu, Yan, Zhang, Junran, Hu, Bingfang, Heyward, Scott, Moeller, Timothy, Xie, Wen, Negishi, Masahiko, Wang, Hongbing
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366797/
https://ncbi.nlm.nih.gov/pubmed/25628225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.097287
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