Efficacy of Flecainide in Catecholaminergic Polymorphic Ventricular Tachycardia Is Mutation-Independent but Reduced by Calcium Overload

BACKGROUND: The dual Na(+) and cardiac Ca(2+)-release channel inhibitor, Flecainide (FLEC) is effective in patients with catecholaminergic polymorphic ventricular tachycardia (CPVT), a disease caused by mutations in cardiac Ca(2+)-release channels (RyR2), calsequestrin (Casq2), or calmodulin. FLEC s...

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Detalles Bibliográficos
Publicado en:Front Physiol
Main Authors: Hwang, Hyun Seok, Baldo, Marcelo P., Rodriguez, Jose Pindado, Faggioni, Michela, Knollmann, Bjorn C.
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2019
Assuntos:
Physiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6701460/
https://ncbi.nlm.nih.gov/pubmed/31456692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2019.00992
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