Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF-β1/Smad3 and TGF-β1/p38 MAPK Pathways

OBJECTIVE: Liver fibrosis is a consequence of wound-healing responses to chronic liver insult and may progress to liver cirrhosis if not controlled. This study investigated the protection against liver fibrosis by isorhamnetin. METHODS: Mouse models of hepatic fibrosis were established by intraperit...

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Detalhes bibliográficos
Publicado no:Mediators Inflamm
Main Authors: Liu, Ning, Feng, Jiao, Lu, Xiya, Yao, Zhilu, Liu, Qing, Lv, Yang, Han, Yuru, Deng, Jingfan, Zhou, Yingqun
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6701280/
https://ncbi.nlm.nih.gov/pubmed/31467486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/6175091
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