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A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration

There has been an explosion in the number of papers discussing the hypothesis of ‘pathogenic spread’ in neurodegenerative disease — the idea that abnormal forms of disease-associated proteins, such as tau or α-synuclein, physically move from neuron to neuron to induce disease progression. However, w...

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Vydáno v:Nat Rev Neurosci
Hlavní autoři: Walsh, Dominic M., Selkoe, Dennis J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6701169/
https://ncbi.nlm.nih.gov/pubmed/26988744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrn.2016.13
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