Dissecting the Innate Immune Recognition of Opioid Inactive Isomer (+)-Naltrexone Derived Toll-like Receptor 4 (TLR4) Antagonists

The opioid inactive isomer (+)-naltrexone is one of the rare Toll-like receptor 4 (TLR4) antagonists with good blood-brain barrier (BBB) permeability, which is a lead with promising potential for treating neuropathic pain and drug addiction. (+)-Naltrexone targets the lipopolysaccharides (LPS) bindi...

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Publicado en:J Chem Inf Model
Main Authors: Zhang, Xiaozheng, Cui, Fengchao, Chen, Hongqian, Zhang, Tianshu, Yang, Kecheng, Wang, Yibo, Jiang, Zhenyan, Rice, Kenner C., Watkins, Linda R., Hutchinson, Mark R, Li, Yunqi, Peng, Yinghua, Wang, Xiaohui
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6700752/
https://ncbi.nlm.nih.gov/pubmed/29518316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jcim.7b00717
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